Kappa Free Light Chain Disease

The kidneys are almost always affected and this often leads to kidney failure.

Kappa free light chain disease.

Light chain deposition usually occurs along with another disease affecting the whole body. Herrera ga joseph l gu x hough a barlogie b. Patients with this disease typically are over the age of 50 and have an average age of 67. Lambda and kappa light chains.

A lower proportion of kappa lcd patients 15 7 than lambda lcd patients 42 2 died within. The age at which you were diagnosed. The risk of developing light chain deposition varies significantly depending on the other disease that the patient has. Ninety seven patients with light chain disease lcd were studied.

There are two types of light chains. There are two types of light chains. Higher levels of free light chains are another sign of developing disease. The level of free light chains another kind of protein in your blood.

Renal pathologic spectrum in an autopsy series of patients with plasma cell dyscrasia. What are light chains. Igm ige and igd types have one much lower incidence. In general the higher the free light chains the more aggressive the disease is.

People with lcdd make too many light chains which get deposited in many body tissues while lcdd can occur in any organ the kidneys are always. This can be measured by the free light chain assay test on a blood specimen. Lcs are normally cleared by the kidneys but in lcdd these light chain deposits damage organs and cause disease. A free light chains test measures the amount of lambda and kappa free light chains in the blood.

Therefore the serum free light chain test is a better predictor of outcome than the amount of m protein in the blood. Light chain deposition disease nodular glomerulopathy kappa light chain deposition disease. The second most common type is the iga myeloma also in combination with any of the two light chains. 65 of patients with myeloma have an igg type.

The disease is more common in men than in women. If the amount of free light chains is higher or lower than normal it can mean you have a disorder of the plasma cells. The median survival from diagnosis was 30 mo for 52 patients with kappa lcd and 10 mo for 45 patients with lambda lcd p less than 0 0007. Light chain deposition disease lcdd is a rare blood cell disease which is characterized by deposition of fragments of infection fighting immunoglobulins called light chains lcs in the body.